Nanoparticelle squaleniche multifunzionali per il cancro del pancreas: aspetti terapeutici e diagnostici

Articolo di ricerca del progetto binazionale della Dott.ssa Valetti Sabrina, finanziato dal programma Vinci 2011 sotto la direzione del Prof. Cattel Luigi dell’Università degli Studi di Torino per la parte italiana e del Prof. Couvreur Patrick dell’Università Paris-Sud XI per la parte francese.
Nanomedicines have gained more and more attention in cancer therapy thanks to their ability to enhance the tumour accumulation and the intracellular uptake of drugs while reducing their inactivation and toxicity.
In parallel, nanocarriers have been successfully employed as diagnostic tools increasing imaging resolution holding great promises both in preclinical research and in clinical settings. Lipid-based nanocarriers are a class of biocompatible and biodegradable vehicles that provide advanced delivery of therapeutic and imaging agents, improving pharmacokinetic profile and safety. One of most promising engineering challenges is the design of innovative and versatile multifunctional targeted nanotechnologies for cancer treatment and diagnosis.

This review aims to highlight rational approaches to design multifunctional non liposomal lipid-based nanocarriers providing an update of literature in this field.

Rational design for multifunctional non-liposomal lipid-based nanocarriers for cancer management: theory to practice
Aggiornato il  31 gennaio 2018