Nanomédicaments squalénés multifonctionnels pour le cancer du pancréas: aspects thérapeutiques et diagnostiques

Article de recherche du projet binational du Dr. Valetti Sabrina, financé par le programme Vinci 2011 sous la direction du Pr. Cattel Luigi de l’Università degli Studi di Torino pour la partie italienne et du Pr. Couvreur Patrick de l’Università Paris-Sud XI pour la partie française.
Nanomedicines have gained more and more attention in cancer therapy thanks to their ability to enhance the tumour accumulation and the intracellular uptake of drugs while reducing their inactivation and toxicity.
In parallel, nanocarriers have been successfully employed as diagnostic tools increasing imaging resolution holding great promises both in preclinical research and in clinical settings. Lipid-based nanocarriers are a class of biocompatible and biodegradable vehicles that provide advanced delivery of therapeutic and imaging agents, improving pharmacokinetic profile and safety. One of most promising engineering challenges is the design of innovative and versatile multifunctional targeted nanotechnologies for cancer treatment and diagnosis.

This review aims to highlight rational approaches to design multifunctional non liposomal lipid-based nanocarriers providing an update of literature in this field.

Rational design for multifunctional non-liposomal lipid-based nanocarriers for cancer management: theory to practice
Mis à jour le  31 janvier 2018